Happy new year! 🍾

• January: Welcome Asako and Yu!

• January 20: We hosted a grand opening celebration at NS4 to mark the launch of the Program in Memory

• January 21: We’re excited to welcome attendees to PML’s first Recruit Symposium. (event link) (agenda)

• March - Quite a lot is happening in the lab!

  • UT Southwestern's Center Times Plus recently featured Prof. Attila Losonczy and the newly established Program in Memory Longevity at the Peter O'Donnell Jr. Brain Institute. The article highlights how the program investigates the neural mechanisms underlying memory disruption and their connection to neurodegenerative disease — combining cutting-edge imaging, electrophysiology, and behavioral approaches to advance understanding of memory resilience across the lifespan. Read the full article →

  • Congratulations to Kevin, Satoshi, Asako, and the rest of the team for their paper accepted in Neuron! Read the article →

  • Welcome, Dana Dodd, our newest lab member!

• April:

  • Karl’s paper about on-demand phototagging is officially out in Neuron. Congrats for the team!

  • Welcome Todd Zheng, our newest postdoc!

  • Also welcome Shobhana, a new staff scientist in the lab!

  • Jason’s new preprint about linking molecular identity to functional properties of CA1 interneurons is on bioarchive.

  • PML research featured in Quanta Magazine

    The Program in Memory Longevity was featured in Quanta Magazine in an article on a newly recognized form of neuroplasticity that may help explain how the brain forms memories after a single experience. The article highlights work on hippocampal circuit rewiring and includes commentary from PML Director Dr. Attila Losonczy on the significance of these findings for understanding learning and memory.

    Read the full article in Quanta Magazine.

• July:

  • Congratulations to Eunji Kong, Erfan Zabeh, and colleagues on their new paper in Neuron!

    Recurrent connectivity shapes spatial coding in hippocampal CA3 subregions

    Using two-photon imaging in behaving mice, the team shows that proximal and distal CA3 support complementary spatial coding strategies — stable representations where recurrent connectivity is low, and dynamic, context-specific coding where it's high — a result confirmed through causal circuit manipulation and neural network modeling. A great step forward in understanding how local circuit architecture shapes hippocampal computation.

  • Welcome Nisha Gamadia, our new Research Assistant!

  • We’re delighted to welcome Bradley Lega, M.D., the William Kemp Clark Chair of Neurological Surgery, and his Texas Computational Memory Lab to the Program in Memory Longevity (PML) at the Peter O’Donnell Jr. Brain Institute. A neurosurgeon and physician-scientist, Dr. Lega studies the electrophysiology of human memory using direct intracranial recordings in patients with epilepsy, bridging clinical care with fundamental discoveries about how the brain encodes and retrieves memories. The collaboration between the Lega and Losonczy groups in PML’s newly dedicated Human Translational Memory Lab focuses on ex vivo physiological, anatomical, and molecular characterization of human brain circuits with advanced electrophysiological, ontogenetic, and transcriptomic approaches.

  • 🍾Big congrats to Asako and colleagues for their freshly published paper in Science! 🍾 Using sub-micron voltage imaging in behaving mice, Asako Noguchi, Satoshi Terada and colleagues show that dendrites don't just relay signals to the cell body — they run their own independent computations, retaining memories of past reward locations, anticipating new spatial patterns, and replaying activity during rest. A paradigm shift for how we think about learning and memory at the single-neuron level. Read the paper → | UTSW Newsroom feature →